Illuminating the Path to Recovery: Transcranial Photobiomodulation (Light Therapy) for Concussion, Cognitive, and Neuropsychiatric Disorders
By Dr. Stefano Sinicropi, Founder of HyperCharge Health
Disclaimer: This blog is for informational purposes only and is not intended as medical advice. The treatments described should only be considered after a consultation and under the direct supervision of a qualified medical expert.
Why is transcranial light and laser therapy so important in the treatment of brain and psychiatric diseases?
Transcranial photobiomodulation (tPBM), a non-invasive therapy utilizing near-infrared (NIR) light to stimulate brain function, represents a paradigm shift in the management of complex neurological and psychiatric conditions. This article provides a comprehensive review of the scientific evidence supporting tPBM. We explore its core mechanisms of action, including the enhancement of mitochondrial respiration, increased cerebral blood flow, and reduction of neuroinflammation. We then analyze the growing body of clinical evidence—from case studies to randomized controlled trials—demonstrating its therapeutic potential and robust safety profile across conditions such as traumatic brain injury (TBI), dementia, Parkinson's disease, depression, anxiety, and PTSD, a therapy we are proud to pioneer here in Minnesota.
The global burden of neurological and psychiatric disorders is staggering, presenting profound challenges to conventional medicine. Conditions like traumatic brain injury (TBI), Alzheimer's disease, and major depressive disorder (MDD) often involve pathologies resistant to standard interventions. In our relentless search for safer, more effective treatments, we are turning to the fundamental principles of cellular bioenergetics. Transcranial photobiomodulation (tPBM) has emerged as a novel therapeutic agent, offering a non-invasive method to directly improve neuronal health.
While this technology is at the global forefront of medical innovation, its availability remains limited. I am proud to say that HyperCharge Wellness Clinics and HyperCharge Integrative Health Clinic, are the only clinics in the state of Minnesota currently offering this advanced Transcranial Light Therapy, bringing world-class restorative neurology to the Twin Cities and beyond. This article will delve into the science that inspired us to become pioneers of this therapy in our state.
The Biophysics of Transcranial Photobiomodulation
Before exploring the clinical data, it is crucial to understand how light can influence brain function. tPBM involves the application of low-power light, typically in the near-infrared (NIR) spectrum (800-1100 nm), to the scalp. This specific range of light has the unique ability to penetrate the skull and reach the cerebral cortex [1]. The energy from photons is absorbed by molecules known as chromophores. The primary chromophore is cytochrome c oxidase (CCO), a critical enzyme in the mitochondrial respiratory chain responsible for producing adenosine triphosphate (ATP), the cell's main energy currency [2].
Mechanism of Action (Detailed)
The therapeutic effects of tPBM are driven by photoneuromodulation. The key mechanisms include:
Enhanced Mitochondrial Respiration: By absorbing NIR light, CCO activity is enhanced, leading to a significant increase in ATP production. This provides neurons with more energy to perform essential functions and repair damage [3].
Increased Cerebral Blood Flow (CBF): Light absorption also causes the photodissociation of nitric oxide (NO), a potent vasodilator. The release of NO increases local blood flow and oxygenation to targeted brain regions [4].
Anti-inflammatory Effects: Neuroinflammation is a key pathological feature in TBI, dementia, and depression. tPBM has been shown to downregulate pro-inflammatory cytokines and shift microglial cells to a pro-repair state [5, 6].
Neurogenesis and Synaptogenesis: tPBM stimulates the release of Brain-Derived Neurotrophic Factor (BDNF), which is essential for neuronal survival and the formation of new connections between neurons [7].
This complex interplay of mechanisms has been elucidated by pioneers in the field. I had the distinct honor of hosting the world's most cited researcher in photobiomodulation, Dr. Michael Hamblin, on my podcast, where we took a deep dive into these cellular effects. You can watch the full discussion here:
Review of Preclinical and Clinical Evidence
The application of tPBM is supported by a rapidly growing body of research.
Traumatic Brain Injury (TBI) and Concussion: TBI is characterized by metabolic disruption and inflammation, which tPBM directly addresses. A randomized, sham-controlled trial on patients with chronic mild TBI found that 18 sessions of tPBM led to significant improvements in executive function, verbal learning, and memory [8]. These published results mirror the profound clinical outcomes we see in our Minnesota clinics. I had the privilege of sharing one such case in my talk, Wellness at the Speed of Light, presented at TEDx. I discussed the story of a 60-year-old gentleman who had suffered a severe concussion, leaving him with debilitating brain fog, memory loss, and emotional instability. After a course of transcranial light therapy, he experienced a dramatic recovery, reporting that "the lights came back on" for the first time since his injury. This is the kind of life-changing result that drives our work.
Cognitive Decline (Dementia and Alzheimer's Disease): A pilot study in Photomedicine and Laser Surgery demonstrated that 12 weeks of tPBM in patients with mild-to-moderate dementia resulted in significant improvements in MMSE scores, better memory, and reduced anxiety [10]. Another study showed tPBM could reduce the pathological amyloid-beta plaque burden in animal models [11].
Parkinson's Disease (PD): In PD, dopaminergic neurons degenerate. Preclinical models have shown that tPBM can protect these neurons and improve motor function [12]. Human case series have demonstrated improvements in motor function (UPDRS scores), gait, and dynamic balance [13].
Major Depressive Disorder (MDD) and Anxiety: Neuroimaging links depression to hypoactivity in the prefrontal cortex. A landmark randomized controlled trial found a single tPBM treatment resulted in a significant and rapid reduction in depression and anxiety scores [14]. Follow-up studies have confirmed these effects, establishing tPBM as a promising, rapid-acting therapy [15]. The lead researcher on one of the most important of these trials, Dr. Paolo Cassano of Harvard University, joined me on the podcast to discuss his groundbreaking work using light to treat mood disorders. Hear directly from the expert here: Wellness at the Speed of Light: Transcranial Photobiomodulation for Mood Disorders with Dr. Paolo Cassano
Post-Traumatic Stress Disorder (PTSD): Preliminary findings from TBI studies, where PTSD symptoms were co-morbid, show significant reductions in hypervigilance and mood lability following a course of tPBM [8].
The HyperCharge Approach: Synergistic Protocols in the Twin Cities
At HyperCharge Health and Wellness Clinics, we believe that a synergistic approach yields the best results. This is particularly true for our patients in Minneapolis, St. Paul, and across Minnesota. We integrate tPBM into comprehensive, personalized protocols. For instance, in a patient recovering from a concussion, we pair tPBM with Exercise with Oxygen Therapy (EWOT). EWOT floods the body's tissues with oxygen, the final and essential ingredient for mitochondrial energy production. By stimulating the mitochondria with light (tPBM) and then providing an abundance of oxygen (EWOT), we create a powerful synergistic effect that dramatically enhances cellular energy and promotes healing. This combination, along with targeted nutritional support and neurofeedback, is a core component of the unique and advanced care we provide. We provide a comprehensive Brain Health assessment at Hypercharge Health in Edina, where we structure a tailored program which may also include physical therapy, acupuncture, peptide management, supplementation. Once a program is created many of the treatments can be administered at our wellness centers in Maple Grove, Woodbury and Eden Prairie.
Safety Profile and Contraindications
One of the most compelling attributes of tPBM is its outstanding safety profile. Large-scale trials of transcranial laser therapy for acute ischemic stroke unequivocally established the therapy's safety, with no significant adverse events compared to sham groups [18, 19]. The energy levels are non-thermal, and the most common reported side effect is a rare, mild, and transient headache. This high degree of safety makes it an ideal therapy to offer our community.
Future Directions and Ongoing Research
The field of tPBM is advancing rapidly. Research is now focused on optimizing treatment parameters for specific conditions. The development of sophisticated home-use devices may soon allow for more accessible, long-term neuro-maintenance protocols, a field we are watching closely from our clinic in the Twin Cities.
Transcranial photobiomodulation is a profoundly important therapeutic tool that addresses the core pathologies of many devastating concussion, cognitive, and neuropsychiatric disorders. With robust clinical evidence and an exceptional safety profile, it represents one of the most promising frontiers in restorative medicine.
For those in Minnesota and the greater Twin Cities area, this advanced therapy is no longer a distant possibility—it is available now. As the sole provider of this treatment in the state, HyperCharge Health is committed to leading the charge and offering new hope for those seeking to recover from injury, enhance cognitive function, and reclaim their mental health.
If you are ready to explore the potential of this groundbreaking therapy, contact HyperCharge Health today to schedule your personalized consultation.
References
Hamblin, M. R. (2018). Photobiomodulation for traumatic brain injury and stroke. Journal of Neuroscience Research, 96(4), 731-743.
De Taboada, L., et al. (2006). Transcranial laser therapy attenuates amyloid-β peptide neuropathology in amyloid-β protein precursor transgenic mice. Journal of Alzheimer's Disease, 8(4), 437-442.
Chung, H., et al. (2012). The nuts and bolts of low-level laser (light) therapy. Annals of Biomedical Engineering, 40(2), 516-533.
Wang, X., et al. (2017). Low-level laser therapy for closed-head traumatic brain injury in mice: transcranial and intranasal routes. Lasers in Surgery and Medicine, 49(6), 631-641.
Hamblin, M. R. (2017). Shining light on the head: Photobiomodulation for brain disorders. BBA Clinical, 7, 113-124.
Xuan, W., et al. (2014). Transcranial low-level laser therapy improves neurological performance in traumatic brain injury in mice: effect of treatment repetition regimen. PLoS ONE, 9(1), e86350.
Meng, C., et al. (2013). The effect of 810 nm light on nerve regeneration in a rat model of sciatic nerve crush injury. Lasers in Medical Science, 28(4), 1145-1151.
Naeser, M. A., et al. (2014). Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study. Journal of Neurotrauma, 31(11), 1008-1017.
Henderson, T. A. (2016). Multi-watt near-infrared light therapy as a neuroregenerative treatment for traumatic brain injury. Neural Regeneration Research, 11(4), 563–565.
Saltmarche, A. E., et al. (2017). Significant improvement in cognition in mild to moderately severe dementia cases treated with transcranial plus intranasal photobiomodulation: case series report. Photomedicine and Laser Surgery
, 35(8), 432
-441.
Purushothuman, S., et al. (2014). Photobiomodulation with near-infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models. Alzheimer's Research & Therapy, 6(1), 2.
Moro, C., et al. (2014). Photobiomodulation preserves behavior and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains. Behavioural Brain Research, 274, 1-7.
Maloney, R., et al. (2015). The potential of photobiomodulation for the treatment of Parkinson's disease. Chromo-endoscopy and Photobiomodulation, 1(2), 79-88.
Schiffer, F., et al. (2009). Psychological benefits of 2 and 4 weeks of daily transcranial application of low-level light therapy to the forehead in patients with major depression: a pilot study. Behavioral and Brain Functions, 5, 46.
Cassano, P., et al. (2018). Transcranial photobiomodulation for the treatment of major depressive disorder: The ELATED-2 pilot trial. Photomedicine and Laser Surgery, 36(12), 634-646.
Lampl, Y., et al. (2007). Laser treatment for stroke: a randomized, controlled trial. Stroke, 38(6), 1843-1849.
Zivin, J. A., et al. (2014). Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke, 45(5), 1359-1364.
Zivin, J. A., et al. (2009). The NeuroThera® Effectiveness and Safety Trial-1 (NEST-1): a randomized trial of transcranial laser therapy with 808-nm infrared light for acute ischemic stroke. Stroke, 40(4), 1359-1364.
Hacke, W., et al. (2014). The NeuroThera® Effectiveness and Safety Trial-2 (NEST-2): a randomized trial of transcranial laser therapy for acute ischemic stroke. Stroke, 45(11), 3187-3193.