In the evolving field of regenerative medicine, innovative approaches are transforming how we address chronic conditions like osteoarthritis (OA) in the knees, shoulders, and even spinal issues. Traditional treatments often focus on symptom management, but regenerative therapies aim to promote healing at the cellular level. Among these, platelet-rich plasma (PRP) and bone marrow concentrate (BMC) injections have gained prominence for their ability to harness the body's natural repair mechanisms. However, not all injection methods are created equal. While intra-articular injections—delivered directly into the joint space—are common and effective for many, emerging evidence highlights the advantages of subchondral intraosseous injections, which target the bone beneath the cartilage. This blog explores the science behind these techniques, dives into key studies comparing them, and discusses why advanced targeting can lead to better outcomes, particularly at specialized clinics like HyperCharge Health and the Institute for Regenerative Medicine.