Modern medicine operates on a linear pharmacological model: "Block the receptor, stop the symptom." This model often fails in complex chronic illness where the primary failure is bioenergetic, not chemical. This whitepaper interrogates the literature surrounding Ozone Therapy (O3), moving beyond its reputation as "alternative medicine" to establish it as a precise oxidative signaling therapy. By reviewing 40 years of international data—including the Madrid Declaration standards—we postulate that Ozone functions not as a drug, but as a hormetic trigger. It acts as a biological "software update" that recalibrates the body’s antioxidant and anti-inflammatory hardware (The Nrf2 Pathway). We propose a novel clinical framework: "The Redox Resuscitation Protocol," positioning Ozone as an integrative adjunct for the "Stalled Engine" of chronic disease.